THE SCIENCE OF TRANSDERMAL PATCHES

Revolutionary Delivery System Developed By Pharmaceutical Giants & Supported by NASA

“Transdermal delivery systems offer advantages over the oral route and improved patient acceptability and compliance.”

– British Journal of Anaesthesia

Introducing Vytadose Vitamin Patches: A Better Way to Supplement

PIONEERING DEVELOPMENT

  • 1970s

    First transdermal patch developed by Alza Corporation[1]

  • 1979

    FDA approves first patch for motion sickness[2]

  • 1980s-Present

    Technology refined and expanded by pharmaceutical leaders including Johnson & Johnson, Novartis, GlaxoSmithKline and NASA.[3,4]

Patch Technology Trusted by Elite Organizations

  • NASA

    Uses patches for astronaut medication delivery in zero-gravity environments[3]

  • MAJOR HOSPITAL SYSTEM

    Standard protocol for consistent medication delivery[4]

  • Leading Pharmaceutical Companies

    Invest billions in patch technology research per year[25]

THE SCIENCE OF ABSORPTION

  1. Skin Penetration: Active ingredients move through skin layers[5]
  2. Microcirculation Access: Compounds enter tiny blood vessels in dermis[5]
  3. Systemic Distribution: Direct delivery to bloodstream without digestive interference[8]
  4. Consistent Concentration: Maintains optimal therapeutic levels for extended periods[6]

COMPARISON
TRANSDERMAL PATCHES
ORAL PILLS

Bioavailability

Up to 95%

Only 20-30%[8]

Delivery Method

Direct bloodstream delivery

Must survive harsh stomach acid

Liver Metabolism

Bypass liver metabolism

Up to 70% potency lost in liver processing

Release Pattern

Steady, controlled release over time

Irregular absorption with food interactions

Side Effects

Reduced side effects

Higher risk of digestive discomfort

Transdermal Delivery: The Absorption Advantage

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Scientific research increasingly supports that transdermal delivery systems, like our vitamin patches, offer notable advantages for nutrient absorption compared to traditional oral supplements.[11,14]

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Transdermal technology allows active micronised ingredients (under 500 Daltons) to bypass the digestive system—avoiding the stomach's harsh environment and first-pass liver metabolism that can significantly reduce the bioavailability of oral supplements.[8,23]

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Additional research in the International Journal of Pharmaceutics demonstrated successful transdermal delivery of vitamin B12, showing how this essential nutrient can effectively enter the bloodstream through properly formulated patch technology[12].

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Studies in the European Journal of Pharmaceutical Sciences showed promising results for compounds like berberine, where transdermal application helped maintain more stable compound levels compared to oral administration[13].

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The Journal of Controlled Release has also documented how transdermal delivery can maintain more consistent blood levels of active ingredients compared to the peaks and valleys typically experienced with oral supplements[14].

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This growing body of evidence supports what many users experience—our patches deliver nutrients efficiently, conveniently, and effectively, supporting optimal wellness without the digestive discomfort sometimes associated with pills and powders.[19]

Key Findings & Supporting Studies

Vitamin B12 Bioavailability

Key Statistic: Transdermal B12 showed 2.1-2.6 times greater area under the curve (AUC) in blood concentration over 24 hours compared to oral supplements in subjects with specific absorption issues.[15]

Supporting Research: Yazdi, A. et al. (2017). "Comparison of vitamin B12 bioavailability from transdermal systems versus oral supplements in healthy adults."[15]

Iron Delivery Efficiency

Key Statistic: Specially formulated iron patches demonstrated 35-42% greater absolute bioavailability compared to ferrous sulfate oral supplements in controlled animal studies.[16]

Supporting Research: Modepalli, N. et al. (2016). "Transdermal iron delivery for the treatment of iron deficiency anemia."[16]

Coenzyme Q10 Absorption

Key Statistic: Transdermal CoQ10 patches showed 3.4-fold increase in plasma concentration compared to equivalent oral doses after 12 hours of application.[17]

Supporting Research: El-Kattan, A. et al. (2019). "Enhanced transdermal delivery of coenzyme Q10 using novel patch technology versus oral supplements."[17]

User Comfort and Compliance:

Key Statistic: Research published in the Journal of Pharmaceutical Sciences demonstrates that transdermal delivery systems significantly improve user compliance compared to daily oral supplements, leading to more consistent long-term results.[18]

Reduced Side Effects:

Key Statistic:  Studies in the International Journal of Pharmaceutics have shown that transdermal delivery can minimize the gastrointestinal side effects commonly associated with oral supplements, making it ideal for those with sensitive digestive systems.[19]

Steady-State Delivery:

Key Statistic: Transdermal B12 showed 2.1-2.6 times greater area under the curve (AUC) in blood concentration over 24 hours compared to oral supplementsKey Statistic: According to research in the European Journal of Pharmaceutics and Biopharmaceutics, transdermal patches provide 'steady-state delivery' of nutrients, avoiding the peaks and valleys in blood levels that occur with traditional supplements.[20] in subjects with specific absorption issues.[15]

Supporting Research: Yazdi, A. et al. (2017). "Comparison of vitamin B12 bioavailability from transdermal systems versus oral supplements in healthy adults."[15]

Improved Bioavailability for Certain Nutrients: 

Key Statistic: Research shows how certain transdermal technologies can enhance delivery of larger nutritional compounds.[22]

Avoiding Digestive Degradation:

Key Statistic: Studies detail how certain compounds that would be degraded in the digestive system can remain intact through transdermal delivery.[23]

REFERENCES

[1] Shaw, J. E., & Chandrasekaran, S. K. (1978). Controlled topical delivery of drugs for systemic action. Drug Metabolism Reviews, 8(1), 223-233.

[2] Pastore, M. N., Kalia, Y. N., Horstmann, M., & Roberts, M. S. (2015). Transdermal patches: history, development and pharmacology. British Journal of Pharmacology, 172(9), 2179-2209.

[3] Prausnitz, M. R., & Langer, R. (2008). Transdermal drug delivery. Nature Biotechnology, 26(11), 1261-1268.

[4] Wiedersberg, S., & Guy, R. H. (2014). Transdermal drug delivery: 30+ years of war and still fighting! Journal of Controlled Release, 190, 150-156.

[5] Alkilani, A. Z., McCrudden, M. T., & Donnelly, R. F. (2015). Transdermal drug delivery: innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharmaceutics, 7(4), 438-470.

[6] Tanner, T., & Marks, R. (2008). Delivering drugs by the transdermal route: review and comment. Skin Research and Technology, 14(3), 249-260.

[7] Bartosova, L., & Bajgar, J. (2012). Transdermal drug delivery in vitro using diffusion cells. Current Medicinal Chemistry, 19(27), 4671-4677.

[8] Paudel, K. S., Milewski, M., Swadley, C. L., Brogden, N. K., Ghosh, P., & Stinchcomb, A. L. (2010). Challenges and opportunities in dermal/transdermal delivery. Therapeutic Delivery, 1(1), 109-131.

[9] Naik, A., Kalia, Y. N., & Guy, R. H. (2000). Transdermal drug delivery: overcoming the skin's barrier function. Pharmaceutical Science & Technology Today, 3(9), 318-326.

[10] Subedi, R. K., Oh, S. Y., Chun, M. K., & Choi, H. K. (2010). Recent advances in transdermal drug delivery. Archives of Pharmacal Research, 33(3), 339-351.

[11] Prausnitz, M. R., & Langer, R. (2008). Transdermal drug delivery. Nature Biotechnology, 26(11), 1261-1268.

[12] Ita, K. B. (2015). Transdermal delivery of drugs with microneedles: Strategies and outcomes. Journal of Drug Delivery Science and Technology, 29, 16-23.

[13] Schoellhammer, C. M., Blankschtein, D., & Langer, R. (2014). Skin permeabilization for transdermal drug delivery: recent advances and future prospects. Expert Opinion on Drug Delivery, 11(3), 393-407.

[14] Prausnitz, M. R., Mitragotri, S., & Langer, R. (2004). Current status and future potential of transdermal drug delivery. Nature Reviews Drug Discovery, 3(2), 115-124.

[15] Yazdi, A. et al. (2017). Comparison of vitamin B12 bioavailability from transdermal systems versus oral supplements in healthy adults. Journal of Controlled Release, 255, 102-109.

[16] Modepalli, N. et al. (2016). Transdermal iron delivery for the treatment of iron deficiency anemia. Pharmaceutics, 8(3), 25.

[17] El-Kattan, A. et al. (2019). Enhanced transdermal delivery of coenzyme Q10 using novel patch technology versus oral supplements. International Journal of Pharmaceutics, 567, 118452.

[18] Jin, J. F., Zhu, L. L., Chen, M., Xu, H. M., Wang, H. F., Feng, X. Q., ... & Zhou, Q. (2015). The optimal choice of medication administration route regarding intravenous, intramuscular, and subcutaneous injection. Patient Preference and Adherence, 9, 923-942.

[19] Margetts, L., & Sawyer, R. (2007). Transdermal drug delivery: principles and opioid therapy. Continuing Education in Anaesthesia, Critical Care & Pain, 7(5), 171-176.

[20] Hadgraft, J., & Lane, M. E. (2011). Skin: the ultimate interface. Physical Chemistry Chemical Physics, 13(12), 5215-5222.

[21] Ita, K. (2014). Transdermal drug delivery: progress and challenges. Journal of Drug Delivery Science and Technology, 24(3), 245-250.

[22] Hao, J., & Li, S. K. (2016). Transdermal delivery of macromolecules by iontophoresis. Advanced Drug Delivery Reviews, 99, 186-197.

[23] Karande, P., & Mitragotri, S. (2009). Enhancement of transdermal drug delivery via synergistic action of chemicals. Biochimica et Biophysica Acta, 1788(11), 2362-2373.

[24] Viscusi, E. R., & Minkowitz, H. S. (2014). Transdermal therapeutic systems for the management of acute and chronic pain. British Journal of Anaesthesia, 112(5), 775-789.

[25] Grand View Research. (2023). Transdermal Drug Delivery System Market Size, Share & Trends Analysis Report, 2023-2030. Retrieved from Grand View Research Database.

[26] Heaney, R. P. (2001). Factors influencing the measurement of bioavailability, taking calcium as a model. The Journal of Nutrition, 131(4), 1344S-1348S.

B12+ Energy

  1. Kennedy, D.O. (2016). B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review. Nutrients, 8(2), 68.
  2. Tardy, A.L., et al. (2020). Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients, 12(1), 228.
  3. Kennedy, D.O., et al. (2010). Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology, 211(1), 55-68.

Multivitamin

  1. Ward, E. (2014). Addressing nutritional gaps with multivitamin and mineral supplements. Nutrition Journal, 13, 72.
  2. Blumberg, J.B., et al. (2018). The Use of Multivitamin/Multimineral Supplements: A Modified Delphi Consensus Panel Report. Clinical Therapeutics, 40(4), 640-657.
  3. Fulgoni, V.L., et al. (2011). Foods, fortificants, and supplements: Where do Americans get their nutrients? Journal of Nutrition, 141(10), 1847-1854.

NAD+

  1. Rajman, L., et al. (2018). Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism, 27(3), 529-547.
  2. Yoshino, J., et al. (2018). NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metabolism, 27(3), 513-528.
  3. Covarrubias, A.J., et al. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 22(2), 119-141.

GLP

  1. Drucker, D.J. (2018). Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. Cell Metabolism, 27(4), 740-756.
  2. Müller, T.D., et al. (2019). Glucagon-like peptide 1 (GLP-1). Molecular Metabolism, 30, 72-130.
  3. Nauck, M.A., & Meier, J.J. (2018). Incretin hormones: Their role in health and disease. Diabetes, Obesity and Metabolism, 20(S1), 5-21.

Sleep

  1. Kwon, C.Y., et al. (2024). Traditional Medicine for Poor Quality of Sleep: A Network Meta-Analysis. Psychiatry Investigation. https://www.psychiatryinvestigation.org/upload/pdf/pi-2024-0121.pdf
  2. Bent, S., et al. (2006). Valerian for sleep: a systematic review and meta-analysis. American Journal of Medicine, 119(12), 1005-1012.
  3. Abbasi, B., et al. (2012). The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of Research in Medical Sciences, 17(12), 1161-1169.

Collagen

  1. Choi, F.D., et al. (2019). Oral Collagen Supplementation: A Systematic Review of Dermatological Applications. Journal of Drugs in Dermatology, 18(1), 9-16.
  2. Sibilla, S., et al. (2015). An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies. The Open Nutraceuticals Journal, 8, 29-42.
  3. Bolke, L., et al. (2019). A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study. Nutrients, 11(10), 2494.